Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. Avoid or Use Alternate Drug. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . Use Caution/Monitor. This site complies with the HONcode standard for trust- worthy health information: verify here. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Human studies not conducted. Either increases effects of the other by pharmacodynamic synergism. Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. Transferrin saturation (TSAT) values increase rapidly after intravenous administration of iron sucrose; do not perform serum iron measurements for at least 48 hours after intravenous dosing. Use Caution/Monitor. 1 Dosing for patients who weigh less than 50 kg Kumpf VJ. Applies only to oral form of both agents. The dosage of Venofer is expressed in mg of elemental iron. Most reactions associated with intravenous iron preparations occur within 30 minutes of the completion of the infusion. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. 1982;13(4):309-21. Uses for Iron Sucrose Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. The dosing for iron replacement treatment in pediatric patients with HDD-CKD has not been established. May increase risk of hypotension. Jacobs P, Dommisse J. Minor/Significance Unknown. Observed Hb = the patients current hemoglobin in g/dl. Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Use alternatives if available. Accessed: 4/12/2011. Otherwise, call a poison control center right away. Medicinal forms Use Caution/Monitor. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Deferasirox chelates iron. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Applies only to oral form of both agents. Venofer® (iron sucrose) injection, USP is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Ferric gluconate: 12.5 mg/mL. https://www.uptodate.com/ (Requires subscription). Avoid or Use Alternate Drug. This website is intended for use by US healthcare professionals only. The dosing for iron replacement treatment in pediatric patients with NDD-CKD or PDDCKD has not - been established. Indicated for treatment of iron deficiency anemia associated with chronic kidney disease, Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week, Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses in over 14 days (cumulative 1000 mg in 14-day period), Peritoneal dialysis-dependent CKD: 300 mg IV infusion (1.5 hr) for 2 doses 14 days apart, THEN 400 mg IV infusion (2.5 hr) 14 days later (cumulative 1000 mg divided in 3 doses/week), Indicated for maintenance treatment of iron-deficient anemia associated with chronic kidney disease, <2 years: Safety and efficacy not established, Iron replacement treatment in pediatric patients has not been established. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or Minor/Significance Unknown.iron sucrose increases levels of calcium citrate by enhancing GI absorption. It should be recognized that iron storage may lag behind the appearance of normal blood morphology. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia. Use Caution/Monitor. Drug Des Devel Ther; 5: 5160. Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events. Med J Aust; 193(9):525-32. Kidney Int. however iron sucrose requires multiple small intermittent doses over days to weeks. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Follow your doctor's directions carefully.Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft).A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. Case G. Maintaining iron balance with total-dose infusion of intravenous iron dextran. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. All Rights Reserved. Iron sucrose: 20 mg/mL. Applies only to oral form of both agents. Applies only to oral form of both agents. Accessed: 4/12/2011. In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . iron sucrose decreases levels of deferiprone by enhancing GI absorption. A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target. Applies only to oral form of both agents. Minor/Significance Unknown. Separate by at least 4 hours. Applies only to oral form of both agents. If these effects continue or worsen, tell your doctor.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Minor/Significance Unknown. 1000 mg. 20 MINUTES. Avoid or Use Alternate Drug. Talk to your pharmacist for more details.During pregnancy, this medication should be used only when clearly needed. Echocardiogram Z Score (NEW)(BETA TESTING) Edinburgh Postnatal Depression Scale. Minor/Significance Unknown. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Applies only to oral form of both agents. 3) Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. (1988) Clinical use of the total dose intravenous infusion of iron dextran. Assessing new treatment options. iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. Applies only to oral form of both agents. Get in touch with MDApp by using the following contact details: 2017 - 2023 MDApp. * Calculators are available in UpToDate to determine ideal body weight and lean body weight. Pediatric Patients (2 Years of Age and Older). Steps on how to print your input & results: 1. The iron deficit calculator is useful as one of the determinations performed before iron replenishment therapy is initiated. prescription products. Medscape Education, Improving Quality of Care in Patients With Iron Deficiency Anemia and Inflammatory Bowel Disease, 2010feosol-carbonyl-fe-icar-c-carbonyl-iron-342171Drugs, encoded search term (iron sucrose (Venofer)) and iron sucrose (Venofer), Use of High-Dose Iron in Dialysis in US Tracks PIVOTAL Trial, FDA Watch List Adds Drugs With Anaphylaxis, Herpes, Fetal Death Risk, Dialysis Industry Mergers: Profits Rise as Patient Outcomes Worsen, Hematology-Oncology Guidelines: 2017 Midyear Review. If hypersensitivity reactions or signs of intolerance occur during administration, stop Venofer immediately. Pregnancy: Risk Summary-Clinical Considerations. There are four variables, all patient parameters, required in the iron deficiency calculator: The patients weight is used in the Ganzoni equation and also when establishing the iron stores. Contraindicated. 4. 1. Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. Patients measured hemoglobin can be input in g/dL or mmol/L. Fatal reactions have followed the test dose of iron dextran injection. Volume of iron product required = 25 mL. Recommended dosing and infusion rates for PI. iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. Monitor Closely (1)esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Schweiz Med Wochenschr; 100(7):301-3. On the other hand, slow decreases, such as that in chronic occult gastrointestinal bleeding are often difficult to diagnose. Applies only to oral form of both agents. Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. commonly, these are "non-preferred" brand drugs. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. Anemia; 2015: 763576. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). US residents can call their local poison control center at 1-800-222-1222. esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. This health tool computes the iron deficit based on patient parameters and the Ganzoni formula. Applies only to oral form of both agents. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Monitor Closely (1)vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. Corrected Calcium. Avoid or Use Alternate Drug. Use Caution/Monitor. Either decreases levels of the other by inhibition of GI absorption. iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Each mL contains 20 mg of elemental iron. Found in multiple references. There are three fields in the parenteral iron replacement for iron deficiency anemia calculator: Weight can be input in either lbs or kilograms and the required transformations are performed by the calculator. Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. When administering as a slow intravenous push, give at the rate of approximately 100 mg (2 mL) per minute. All Rights Reserved. Foods rich in iron include meats (especially liver), eggs, raisins, figs, broccoli, brussels sprouts, beans, lentils, and iron-fortified or enriched cereals. ------------------------------------------------------------------------- Iron Dextran Complex [ Infed ] Elemental iron: 50 mg of elemental iron per mL [2 mL] [package insert] BOXED WARNING: WARNING: RISK FOR ANAPHYLACTIC-TYPE REACTIONS Anaphylactic-type reactions, including fatalities, have followed the parenteral administration of iron dextran injection. Modify Therapy/Monitor Closely. This calculator will help pinpoint potential causes of anemia based on Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). Use Caution/Monitor. Results: Twelve children (6 females) aged 1.2-14 years (median age 8.9 years) received at least one dose of . Avoid or Use Alternate Drug. 2010niferex-hytinic-polysaccharide-iron-342160Drugs, You are being redirected to Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. Minor/Significance Unknown. Dosage: For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Use Caution/Monitor. Monitor Closely (1)trientine, iron sucrose. Applies only to oral form of both agents. iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Applies only to oral form of both agents. The recipient will receive more details and instructions to access this offer. Applies only to oral form of both agents. Total dose iron infusion: safety and efficacy in predialysis patients. There are four fields that need to be completed: Weight body weight is used to establish iron deficit and is also taken into account when estimating the iron stores. In the text below the tool there is more information on how the iron deficit is calculated. Minor/Significance Unknown. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Applies only to oral form of both agents. IDA symptoms are often nonspecific and include tiredness, weakness, shortness of breath. Applies only to oral form of both agents. You may report side effects to Health Canada at 1-866-234-2345. sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Ferritin and transferrin are also recommended monitoring . Modify Therapy/Monitor Closely. Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. DICP. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. Modify Therapy/Monitor Closely. aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Hemoglobin iron deficit = 60 x (14 - 8) x (2.145) = 772 mg iron. Calculosaurus | Medical calculators for obstetrics and gynaecology Use the menu to browse through our clinical calculators. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. STORAGE: Consult the product instructions and your pharmacist for storage details. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. Applies only to oral form of both agents. . Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. This iron deficiency calculator determines the iron deficit based on patient weight, hemoglobin and iron stores to prepare for iron replacement. Applies only to oral form of both agents. Minor (2)calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. . https://www.uptodate.com/ (Requires subscription). Applies only to oral form of both agents. ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. We'll do this entirely for free, as long as the calculator has applications for women's health. Finally, a 400-mg dose by 2-hour infusion was examined in 35 patients, but 2 patients experienced such symptoms as hypotension, nausea, and lower back pain. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. In less advanced cases of iron deficiency, increases in dietary intake of iron may be sufficient. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hgb conc. Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. iron sucrose increases levels of calcium citrate by enhancing GI absorption. Your dosage and length of treatment are based on your medical condition, age, and response to treatment. Monitor Closely (1)cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. March 2, 2015 [IRON SUCROSE REQUIREMENT CALCULATION FOR SEVERE ANEMIA] DPMU Anantapuramu | National Health Mission 1 Formula for calculating the required dose of Iron sucrose 2.4 X Pre-pregnancy Weight in Kgs X Hb% deficit{11-actual Hb%} in mgs Plus Iron required to replenish the iron stores = 500mg Prepregnancy Weight = 45 kgs . Monitor Closely (1)deferasirox decreases levels of iron sucrose by inhibition of GI absorption. Parenteral iron supplementation. 2015: 763576. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. The dosage of Venofer is expressed in mg of elemental iron. Due Date form Ultrasound Report. Schrier SL, Mentzer WC, Landaw SA. Dosing: (a) Divide calculated total cumulate dose . Modify Therapy/Monitor Closely. Minor/Significance Unknown. Nutrition. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. Injectafer treatment may be repeated if iron deficiency anemia reoccurs. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. This parenteral iron replacement for iron deficiency anemia calculator determines the parenteral dose of iron supplement needed to replenish iron stores and hemoglobin levels. Give each dose as 15 mg/kg body weight for a total cumulative dose not to exceed 1500 mg of iron per course. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. Use Caution/Monitor. No additional iron to replenish stores. May increase risk of hypotension. IDA symptoms vary, may not be specific and include tiredness, weakness, shortness of breath. Manufacturer advises for slow intravenous injection ( Venofer ), give undiluted at a rate of 1 mL/minute; do not exceed 10 mL (200 mg iron) per injection. Use Caution/Monitor. PRECAUTIONS: Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Use Caution/Monitor. informational and educational purposes only. Step 2: Calculation and administration of the maximum individual iron dose(s): . ]Venofer treatment may be repeated if iron deficiency reoccurs. Recommended dosage for patients weighing less than 50kg (110lb): Give Injectafer in Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Separate by 2 hr. Avoid or Use Alternate Drug. 2012;2(4):288-335. Applies only to oral form of both agents. Avoid or Use Alternate Drug. calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. FOR PATIENTS WEIGHING 50 kg OR MORE: Administer 1000 mg of Monoferric by intravenous infusion 20 minutes as a single dose 1. The dosing for iron replacement treatment in pediatric patients with hemodialysis-dependent chronic kidney disease (HDD-CKD), non-dialysis-dependent chronic kidney disease (NDD-CKD) or peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD) has not been established. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) Elemental iron product this is a choice between three iron supplement products: Iron dextran 50 mg/mL, Iron sucrose 20 mg/mL and Ferric gluconate 12.5 mg/mL. iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Only administer Venofer when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. Use Caution/Monitor. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. A healthcare provider will give you this injection. (3) Known hypersensitivity to Venofer. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Sodium ferric gluconate (Ferrlecit) 62.5 mg . Minor/Significance Unknown. In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. Applies only to oral form of both agents. Assessing new treatment options, Intravenous iron-dextran: therapeutic and experimental possibilities. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time.Your dosage and length of treatment are based on your medical condition, age, and response to treatment. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling (16.2). Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. These can be input in g/dL, g/L or mmol/L. Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to INFeD. Intravenous iron sucrose: establishing a safe dose. Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Use Caution/Monitor. Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL This drug is available at a higher level co-pay. MDCalc loves calculator creators researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. Copyright(c) 2023 First Databank, Inc. Use Caution/Monitor. LBW = Lean body weight in kg. Normal haemoglobin values are gender specific: for males from 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and females from 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Most Venofer (iron sucrose) dose calculator | Calculosaurus.com Clinical calculators for obstetrics and gynaecology VTE risk assessment Calculator menu Venofer dose calculator Iron sucrose Not what you were looking for? Schweiz Med Wochenschr; 100(7):301-3. In a randomized, open-label, dose-ranging trial for iron maintenance treatment with Venofer in pediatric patients with CKD on stable erythropoietin therapy [see Clinical Studies ( 14.7)], at least one adverse reaction was experienced by 57% (27/47) of the patients receiving Venofer 0.5 mg/kg, 53% (25/47) of the patients receiving Venofer 1 mg . Separate by at least 4 hours. Each mL contains 20 mg of elemental iron. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session [see How Supplied/Storage and Handling (16.2).] trientine, iron sucrose. Administer Venofer early during the dialysis session (generally within the first hour). Applies only to oral form of both agents. Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD): Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Calculates iron deficit for dosing iron. Dosing Administration & Considerations . Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Use Caution/Monitor. Equations used: 1] Calculation of the Total Iron Deficit: Total iron deficit [mg] = body weight [kg] x (target Hb-actual Hb) [g/dl] x 2.4 + depot iron [mg]. Serious - Use Alternative (1)iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Applies only to oral form of both agents. Venofer may cause clinically significant hypotension. Use alternatives if available. Modify Therapy/Monitor Closely. Where: Medicine concentration Amount of active substance per a given volume of your drug. FERAHEME Dosing & Administration - Feraheme FERAHEME has flexible dosing for your patients FERAHEME flexible scheduling gives your patients the freedom to receive the iron they need as early as 3 days apart 1 FLEXIBLE DILUTION OPTIONS 1 Dilute full contents of vial (17 mL) in 50 mL to 200 mL of: 0.9% NaCl, or 5% dextrose STORAGE 1 The dosing of Monofer was performed according to the Simplified Table as described in section 4.2 above and dosing of iron sucrose was calculated according to Ganzoni and administered as 200 mg infusions.