4 If you want to impress your teacher, tell her that some bacteria do ⦠7. However, in eukaryotic cells, the DNA is linear and, as discussed above, is associated with histone proteins. 6. ADVERTISEMENTS: The upcoming discussion will update you about the differences between Prokaryotic DNA and Eukaryotic DNA. 1. Number of chromosomes Prokaryotic DNA is circular and is neither associated with histones nor organized into chromosomes. Prokaryotic cells all have small ribosomes, whereas eukaryotic all have larger ribosomes. Note that viruses are not cells, by DNA with a protein coating. Disadvantage (from a eukaryotic standpoint) is that you cannot have crossing over with circular DNA. ... ⢠Usually single, circular DNA molecule ⢠No membrane bound organelles ⢠Cell walls almost always contain peptidoglycan ⢠Divide by binary fission â¢Sz