As previously noted, the safety of intranasal zinc has been called into question because of numerous reports of anosmia (loss of smell), in some cases long-lasting or permanent, from the use of zinc-containing nasal gels or sprays [17-19]. Zinc helps maintain the integrity of skin and mucosal membranes [52]. Dietary intakes and serum nutrients differ between adults from food-insufficient and food-sufficient families: Third National Health and Nutrition Examination Survey, 1988-1994. Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans. Laryngoscope 2006;116:217-20. [, Nishi Y. Zinc and growth. Role of zinc in the process of pancreatic fibrosis in chronic alcoholic pancreatitis. They recommend use of an AREDS formulation providing 80 mg zinc [79,80]. Ervin RB, Kennedy-Stephenson J. Solomons NW. Estimated Average Requirement (EAR): Average daily level of intake estimated to meet the requirements of 50% of healthy individuals; usually used to assess the nutrient intakes of groups of people and to plan nutritionally adequate diets for them; can also be used to assess the nutrient intakes of individuals. Zinc is the second most abundantly distributed trace element in the body after iron.1 Zinc catalyzes enzyme activity, contributes to protein structure, and regulates gene … In addition, vegetarians typically eat high levels of legumes and whole grains, which contain phytates that bind zinc and inhibit its absorption [34,41]. Acta Paediatr Scand Suppl 1985;319:158-63. Eur J Clin Pharmacol 1975;9:131-4. Reductions in a copper-containing enzyme, a marker of copper status, have been reported with even moderately high zinc intakes of approximately 60 mg/day for up to 10 weeks [2]. WHO/UNICEF Joint Statement, August, 2004. An element with atomic symbol Zn, atomic number 30, and atomic weight 65.39. metallic trace element, atomic symbol Zn, atomic number 30; necessary in the diet, forms an essential part of many enzymes, and plays an important role in protein synthesis and in cell division. However, the authors of a systematic review and meta-analysis published in 2007 concluded that zinc is not effective for the primary prevention of early AMD [77], although zinc might reduce the risk of progression to advanced AMD. INGREDIENTS: Each blue and pink capsule contains 50 mg. of elemental zinc. The U.S. Food and Drug Administration (FDA) developed DVs to help consumers compare the nutrient contents of foods and dietary supplements within the context of a total diet. An analysis of NHANES III data found that 35%–45% of adults aged 60 years or older had zinc intakes below the estimated average requirement of 6.8 mg/day for elderly females and 9.4 mg/day for elderly males. More recently, a Cochrane review concluded that "zinc (lozenges or syrup) is beneficial in reducing the duration and severity of the common cold in healthy people, when taken within 24 hours of onset of symptoms" [73]. The Dietary Guidelines for Americans describes a healthy eating pattern as one that: This fact sheet by the Office of Dietary Supplements (ODS) provides information that should not take the place of medical advice. Studies have shown that both zinc acetate and zinc gluconate are effective at shortening the length of a cold. Packaging and Presentation . Alaimo K, McDowell MA, Briefel RR, et al. These values, which vary by age and gender [2], include the following: The current RDAs for zinc are listed in Table 1 [2]. Clinical and laboratory assessment of zinc deficiency in Dutch children. Int J Food Sci Nutr 1995;46:53-63. It is a zinc molecular entity and an acetate salt. Zinc … Understanding zinc: recent observations and interpretations. Zinc oxide is one such chemical compound that contains zinc … [, Wang LC, Busbey S. Images in clinical medicine. For a dose of 50mg elemental zinc, take 385 mg zinc gluconate. I discover it ironic that I had a zinc deficiency for years with out realizing it… particularly as a result of I’d written a senior biology paper on the. [, Meydani SN, Barnett JB, Dallal GE, Fine BC, Jacques PF, Leka LS, et al. Approximately 30%–50% of alcoholics have low zinc status because ethanol consumption decreases intestinal absorption of zinc and increases urinary zinc excretion [47]. In more severe cases, zinc deficiency causes hair loss, diarrhea, delayed sexual maturation, impotence, hypogonadism in males, and eye and skin lesions [2,8,27,28]. Zinc acetate is also called zinc salt dihydrate or zinc … Absorption interactions with fluoroquinolones. J Nutr 2003;133:1485S-9S. [. Am J Rhinol 2004;18:137-41. However, in zinc … The effects of zinc supplementation on diarrhea in children with adequate zinc status, such as most children in the United States, are not clear. But still … Thiazide diuretics such as chlorthalidone (Hygroton®) and hydrochlorothiazide (Esidrix® and HydroDIURIL®) increase urinary zinc excretion by as much as 60% [93]. Thus, the bioavailability of zinc from grains and plant foods is lower than that from animal foods, although many grain- and plant-based foods are still good sources of zinc [2]. Drug Saf 1995;12:314-33. [, Caruso TJ, Prober CG, Gwaltney JM Jr. Biol Trace Elem Res 1995;49:211-25. [, Wilkinson EA, Hawke CI. Urinary zinc excretion during treatment with different diuretics. The doses of zinc used in the AREDS study (80 mg per day of zinc in the form of zinc oxide for 6.3 years, on average) have been associated with a significant increase in hospitalizations for genitourinary causes, raising the possibility that chronically high intakes of zinc adversely affect some aspects of urinary physiology [88]. Zinc acetates are prepared by the action of acetic acid on zinc carbonate or zinc … Although access to this website is not restricted, the information found here is intended for use by medical providers. J Am Pharm Assoc (2003) 2004;44:594-603. BMJ 2003;326:409-10. Dietary intake of antioxidants and risk of age-related macular degeneration. Your healthcare provider may occasionally change your dose to make sure you get the best results from zinc acetate. Zinc Acetate: 25 mg (7.5 mg elemental zinc), 50 mg (15 mg elemental zinc) Zinc Gluconate: 50 mg (7 mg elemental zinc), 100 mg (14 mg elemental zinc) Zinc Sulfate: 110 mg (25 mg elemental zinc), 220 mg … The U.S. Department of Agriculture's (USDA's) FoodData Central [11] lists the nutrient content of many foods and provides a comprehensive list of foods containing zinc arranged by nutrient content and by food name. [, Prasad AS, Beck FW, Bao B, Snell D, Fitzgerald JT. Neurology. Zinc Acetate: This type of zinc supplement is made with citric acid. FPnotebook.com is a rapid access, point-of-care medical reference for primary care and emergency clinicians. Zinc is an essential mineral that is naturally present in some foods, added to others, and available as a dietary supplement. Numerous case reports of anosmia (loss of the sense of smell), in some cases long-lasting or permanent, have been associated with the use of zinc-containing nasal gels or sprays [17,18]. It is required for the catalytic activity of approximately 100 enzymes [1,2] and it plays a role in immune function [3,4], protein synthesis [4], wound healing [5], DNA synthesis [2,4], and cell division [4]. Zinc deficiency and taste disorders. Zinc supplements have the potential to interact with several types of medications. † Zinc Oxide: Zinc … Equivalent to 1 mg elemental zinc … Common Zinc Salt Products • Zinc gluconate lozenge … 13.3 mg elemental zinc • Zinc sul… However, some evidence suggests that zinc intakes among older adults might be marginal. [, van Leeuwen R, Boekhoorn S, Vingerling JR, Witteman JC, Klaver CC, Hofman A, et al. J Trace Elem Med Biol 2006;20:3-18. [, Navarro S, Valderrama R, To-Figueras J, Gimenez A, Lopez JM, Campo E, et al. Supplements contain several forms of zinc, including zinc gluconate, zinc sulfate, and zinc acetate. 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