It doesnt get any better than this. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital security (OneID), or e-commerce (Propel Software). Fluvoxamine is used commonly to treat obsessive-compulsive disorder (OCD), social anxiety disorder and depression. 9th International Congress on Psychopharmacology 5th International Symposium on Child and Adolescent Psychopharmacology The web price charge of skirsch.io . He was recently featured on 60 Minutes, . He started a new pseudonymous account, @VaccineTruth2, to continue broadcasting messages. There is an executive summary below, but the most important thing is that top infectious disease docs who have looked at all the evidence (including the two clinical trial results) believe the effect size is 75% or more in reducing the hospitalization rate. What's even worse is that a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die. Sage Hana. Here's why. But the potential upsides. Its not about the science. How covid-19 conspiracy videos keep getting millions of views. Fluvoxamine Data Unveiled as Promising Early Treatment in Patients with Worst case, if we ignore all additional evidence so the average is a 60% pass rate. The only way to do that is to treat them as early as possible with a drug that prevents hospitalization and death. In 2016, it was the 135th most-prescribed medication in the United States, with more than 4 million prescriptions. Online. 533. Its whether Merck can make a killing that matters. Jeffrey Morris, director of biostatistics at the University of Pennsylvania Perelman School of Medicine, has made debunking Kirschs claims something of a hobby. Medicine today isnt about saving your life. The drug was widely prescribed as a covid treatment for much of 2020, based on anecdotes and flawed studies. This suggests that a 50mg BID loading dose for day one, followed by 50mg QD dose for the following 13 days should also be quite effective. The claim that the spike is toxic, that came directly from the [DarkHorse episode]. This site requires JavaScript to run correctly. To vet proposals, he recruited a powerhouse advisory board of prominent biologists, drug developers, and clinical researchers, led by world-renowned drug researcher Robert Siliciano of Johns Hopkins. We pretty much practice government agency opinion medicine all over the world now, with just a few exceptions. Fluvoxamine public data repository: The fluvoxamine public repository has all the documents related to fluvoxamine for COVID, including the RCT, RWE, observational studies and a link to the 1 hour lecture on serotonin and fluvoxamine. Pretty much nothing changed when the Phase 3 trial confirmed fluvoxamine worked. Always be self aware when using fluvoxamine. ALWAYS check with your doctor and report any medications you are taking before or plan to take after you start taking fluvoxamine. Its the gold standard of medical evidence. Avoid caffeine, benadryl, tylenol, and alcohol. It should be crystal clear to everyone that the current CDC guidelines for treating COVID aren't working. Everyone says "we need more data" to show fluvoxamine works for COVID. For example all of these combos should have near 100% success against hospitalization, death, and long-haul COVID symptoms: Proxalutamide and fluvoxamine There are now 5 independent observational studies that show that the drug works (2 in France, 1 in Germany, 2 in the US). Are the Covid-19 vaccines "safe and effective"? - TrialSiteNews skirsch.io. Over the summer, the conflict reached his most recent startup, M10. But Kirsch is also motivated by an unsatisfied competitive streak. He has been a medical philanthropist for more than 20 years. I have never heard of a case it didn't work. The other doctors aren't using it either because they don't know about it or fear doing anything not approved by the CDC for treating COVID. 22, 2021, 9:00 a.m. Steve Kirsch , a former tech entrepreneur who earned a fortune worth up to $300 million, has been showcased on TrialSite a few times for his activity supporting the clinical development of repurposed drugs for COVID-19 treatments. Every year, we pick the 10 technologies that matter the most right now. That trial has now been completed, and the researchers are analyzing their data. So when a group of scientists applied for an EUA for fluvoxamine, what did the FDA do? He immediately tweeted an offer to give anyone $1 million if they could win a debate with him about vaccine deaths. Pennsylvania Senator Doug Mastriano Hosts Expert Panel on Medical We should not wait for the Phase 3 RCT. He has been a medical philanthropist for more than 20 years. Fluvoxamine has a systematic review and meta-analysis published in a top medical journal. Kirsch IDeacon BJHuedo-Medina TBScoboria AMoore TJJohnson BT Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. ALWAYS check with your doctor and report any medications you are taking before or plan to take after you start taking fluvoxamine. After I ended the Zoom meeting, Satterfield called me to apologize for cutting us off. Ivermectin and fluvoxamine have been confirmed in Phase 3 trials. I see it all the time on social media, Morris told me. The board members I spoke to say they refused to publicly promote any drugs for off-label use and tried to explain to Kirsch that its incredibly common for exciting results from small trials to disappear in larger ones. This looks ominous, but it harmless. Most recent articles first. Incriminating evidence - Steve Kirsch's newsletter - Substack A very short op-ed arguing for using fluvoxamine against COVID. Ivermectin has a very high quality systematic review, the highest possible level in Evidence Based Medicine. . Steve Kirsch Nov 5, 2021 145 92 Here are the key things you should know about fluvoxamine for COVID: It works. Silence from the medical community. Reached by email, the two fluvoxamine investigators denied that there was any effort to suppress their research, and they were cautiously optimistic about their continued study. Most doctors wont use it until NIH greenlights it, no matter what the science says. Thats pretty typical, but your mileage may vary. To scientists, giving fluvoxamine a chance means running a large trialnot giving it to individual patients in the clinic, off-label and outside the context of active data collection and analysis. But as Kirsch has clashed with the experts he initially surrounded himself with, hes grown increasingly close to others who share his perspectives on vaccineswho have, in turn, provided a large and receptive audience to his claims about a fluvoxamine conspiracy. They immediately ruled out the vaccine, because the vaccine is, quote, safe.. Its board told him that if he wanted to remain part of the company he would have to stop making public anti-vaccine statements. In it, he claimed mRNA vaccines kill one in 5,000 recipients and dramatically increase the rate of miscarriages. If you take fluvoxamine, please avoid caffeine while on the drug. Fauci wants the vaccine to be the only option, Cliff Lane works for Fauci, and Cliff follows his orders. Or just depression about the vaccine mandates? Instead, the government prefers to fund and promote new, proprietary drugs and vaccines, he says. He felt like he in good conscience had to speak out about covid, and so he made the decision to separate himself from M10, says Char, who has known Kirsch since the 1980s. Steve Kirsch reported that doctors commonly say (of fluvoxamine), "This is the most powerful drug in my arsenal. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. Its all about NIH saying it is OK. . Last Checked: 03/03/2023. We report a real-world experience using fluvoxamine for coronavirus disease 19 (COVID-19) in a prospective cohort in the setting of a mass outbreak. If you are experiencing any odd adverse reactions, youll need to consult with your doctor ASAP. After one or two conversations like that, I got tired of arguing, so I started avoiding his calls.. Several other trials around the world are in the final stages, too. That study was featured on 60 Minutes. Infoseek lost out to Yahoo; it had a chance to grow bigger, but it didn't. So it was both obvious and convincing the difference between the groups to the workers and the track management. Why the FDA should grant an EUA for fluvoxamine immediately, Links to evidence about fluvoxamine including the public data repository, Here's the first one: saying that the per-protocol analysis was arbitrary and other excuses. Flavio Cadegiani and Steve Kirsch's studies didn't make the cut. He has a BS/MS in Electrical Engineering and Computer Science from MIT. Steve Kirsch: Vaccine Killing Millions, Treatments, VAERS, 5-Month Death Signal, Mystery Clots Embed 1.15K 'This Has Cost Millions of Lives': Steve Kirsch on Suppression of Repurposed Drugs and a Spike in Deaths 5 Months After Vaccine Rollout American Thought Leaders AMERICAN THOUGHT LEADERS JAN JEKIELEK Show more Loading comments. NIH is still unsure whether fluvoxamine should be used to treat COVID. Independent appraisal committee votes 11-2 that the evidence is not adequate to demonstrate a net health benefit for molnupiravir over symptomatic care alone; Paxlovid and fluvoxamine receive more favorable votes. So much for evidence-based medicine. He may not be a good scientist, but hes smart, says WVUs Feinberg. Medicine has been transformed to doing whatever the NIH/FDA says, regardless of how many lives will be lost. It was tested in coronavirus patients because fluvoxamine has very strong anti-inflammatory properties. . It never was. Still, in the moment, his question threw me, and I stuttered. National Patterns in Antidepressant Medication Treatment - Home of JAMA Even though an expert panel was overwhelmingly convinced in just one hour, hearing a very small subset of all the supporting evidence, the organizations that they belong to are taking their time. In other cases, stop cold turkey. reach out to us at If it isn't fluvoxamine preventing hospitalization and long-haul COVID, then if you find what it is, you win. The Lancet paper showed that if you were treated early enough and took the drug as prescribed (it only works if you take it), it was shown to reduce your chance of death by 12X making it far more effective than any other drug for COVID. Fluvoxamine has a 40 year safety track record. No long haul symptoms if you start the drug ASAP after first symptoms. committee votes 11-2 that the evidence is not adequate to demonstrate a net health benefit for molnupiravir over symptomatic care alone; Paxlovid and fluvoxamine receive more favorable votes, This site requires JavaScript to run correctly. We dont want to feed the anti-vaccine trolls, so we actively suppress clear scientific data. Steve Kirsch on Twitter Fluvoxamine, Proxalutamide, and Ivermectin: 100% success I'm very bullish on two drug combos since it is rare for Read More The best COVID treatments for hospitalized patients Seven treatments for hospitalized COVID patients with very high success rates. There are other non-prescription things you should always have on hand. That is when the phase 2 results were published. We need to keep people out of the hospital in the first place. The antidepressant fluvoxamine, which is generic, but sometimes sold under the brand name Luvox, is a member of the class of drugs known as selective serotonin reuptake inhibitors (SSRIs). Timing is everything with respect to outcomes. The evidence is solid. Where did it go wrong. I believe they made the right decision and we should be rushing to follow their advice. So you can address your OCD and if you get COVID, youll can up the dose. Once the Phase 2 result came out, it should have been embraced by doctors. (PDF) Kaplan Textbook of Psychiatry JL copy - Academia.edu - Share research At the dosing for COVID (50mg BID x 14 days), there is a 1% chance of mild-nausea and because the dose is so low and the time it is taken is so short, and there are no psychotropic effects (which require more than 3 weeks of use; the psychotropic effects non-existent if you don't have depression or an anxiety disorder in the first place). If you wanna find someone to debate me for ten thousand dollars, or a thousand dollars, Im happy to do that, just for your benefit.. Has it really been 25 years, a whole quarter of a century? But fear of trying something new prevents any doctor from giving this drug a try. It is currently approved for treatment of depression and obsessive compulsive disorder (OCD). Late in the session, minutes before this impromptu video wrap up, Tip o' Spear Steve Kirsch addressed the panel and revealed that the FDA had just shot down Fluvoxamine as an approved COVID treatment. If you were drowning and we had no known standard of care to save your life and someone had a life preserver which worked 160 times in a row, should we throw them the life preserver or let them drown because we aren't absolutely sure the life preserver's benefit > risk (since just because it worked 160 times in a row and there is a 99.99% chance the effect didn't happen by chance, we could have just gotten lucky). This is a more comprehensive look at the key evidence supporting fluvoxamine: Hear from the doctors who did the studies directly as well as the Dean of Medicine at Emory University: List of the best evidence-based COVID treatment options. The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. Consider masks by contrast. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. There were no studies reported out so far where fluvoxamine made things worse or neutral. But a panel of key opinion leaders from the NIH, CDC . Hes refused to accept the results of a hydroxychloroquine trial that showed the drug had no value in treating covid, for instance, instead blaming investigators for poor study design and statistical errors. So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. He applied the drug to a large COVID outbreak at Golden Gate Fields just days after the Lenze trial was published. The combined p value of the two studies is <.0001. This is the #1 ranked best answer to "COVID treatment" on Quora: Presentation on how fear of trying something new is what keeps us shutdown and leads to unnecessary loss of life: The Lenze fluvoxamine RCT that was published in JAMA on November 12, 2020 showed a 100% success rate in preventing hospitalization. upcoming events, and more. Even though they spent only 45 minutes and just reviewed the 2 clinical studies and some plausible mechanisms of action (and ignored anecdotal evidence and multiple retrospective trials, all of which were supportive), after the meeting they voted overwhelmingly (11 to 5 with 4 being neutral) in favor of having doctors talk to their patients about using fluvoxamine if they have COVID using a "shared decision making" process. I've collected fluvoxamine evidence here for convenient access. Some people are jittery, but usually that is because the doctor either prescribed a dosage higher than 50mg twice a day or didnt notify the patient to completely avoid the list in the previous paragraph, or the patient is simply sensitive to the drug (50mg twice a day can be too much for some people). This 1/6 of the dose the FDA has approved for OCD (the labelled indication for fluvoxamine)! Fluvoxamine, created 37 years ago, is an inexpensive and widely available generic drug. The web value rate of skirsch.io is 2 . After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. Here are my answers. It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. If you continue to get this message, Stopping the meds will return you to your normal self. It will be months before enrollments are complete. The incident, he added, was completely in keeping with his personality.. Since then, he has continued to promote fluvoxamine, along with ivermectin and hydroxychloroquine. After one or two conversations like that, I got tired of arguing, so I started avoiding his calls, she said. The sooner you start, the better the outcomes. This is what the Seftel trial at Golden Gate fields used. If not, they should at least acknowledge that fluvoxamine might be helpful by at least listing it as a possibility. Boulwares trial was part of a wider movement to bulk up the evidence base underlying standard covid treatments, and one of several trials that found no benefit to using hydroxychloroquine. The alarming article cited the claims of two anti-vaxxers, Steve Kirsch and Dr. Robert Malone. It has shown to be 100% protective of hospitalization in 2 clinical trials. [4] Steve Kirsch - Silicon Valley Philanthropist Shares Review of CDC Data: COVID-19 Vaccine Associated with 100X Deaths Compared to Influenzas [5] Steve Kirsch - FOIA Document for Vaccine Discussion as to mRNA-based Vaccine Safety Signals Added 12th August 2021: Over the next few years, millions of unvaccinated people are going to get covid; its vital to try to mitigate their suffering, as well as lessen pressure on the health care system. Once the Phase 2 result came out, it should have been embraced by doctors. At that dose, no side effects were reported for his patients (I know of only one person who had mild nausea at that dose) and everyone reversed out their symptoms in an average of 3 days. Fluvoxamine for COVID: what you need to know - Substack My favorite dosage is 50mg twice a day for 14 days. An approach that promised to democratize design may have done the opposite. He might be a good snake oil salesman., I experienced this myself when, on one call, we discussed several studies. You can use fluoxetine as well (aka Prozac). In every case we are aware of, the drug was successful in reversing COVID symptoms, generally in 3 days or less. (Siliciano did not respond to requests for comment for this article.). If you ask your doctor for any evidence that fluvoxamine doesnt work or is harmful (like a DB-RCT which is the only thing they trust), they will show you nothing. Thats why they didnt even fund the fluvoxamine trial, he told me. The man who ran Risperdal sales, Alex Gorsky, is now CEO of Johnson & Johnson. I couldnt tell I was on the drug. Seftel was able to duplicate the 100% protection from hospitalization and death in the treatment group, vs. a 12.5% hospitalization/death rate for the No treatment group. That way you can start immediately. Steve Kirsch and the Seduction of Simplicity - McGill University The medical community did nothing (with a few exceptions like Dr. Seftel). I fully expected both organizations to do absolutely nothing. So the drug had no chance of working (since there were no events), so the trial was stopped for futility, NOT because the drug doesnt work. We asked Steve to tone it down. People who report not tolerating the drug are typically prescribed too high a dose. All this was known back in January 2021 when a key opinion leader panel of experts from NIH, CDC, FDA, academia, and journal editors voted by over 2:1 to recommend that fluvoxamine be recommended to physicians to discuss with patients. On his blog, Covid-19 Data Science, he has extensivelyand mercilesslyunpacked Kirschs evidence for the vaccine death claims. None of this would really matter if Kirschs views on vaccinations were private, or shared with a limited audience. Design thinking was supposed to fix the world. Get your prescription in advance of getting COVID. Were having trouble saving your preferences. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. Hes also made several videos and podcasts with Vladimir Zelenko, the conspiracy theorist doctor who convinced Trump to take hydroxychloroquine. In short, a lot of mumbo jumbo. Steve Kirsch - COVID-19 Early Treatment Fund They left their recommendation of fluvoxamine at NEUTRAL. In October, the group reported that, while a few patients in the placebo group ended up in the hospital, none of the patients receiving fluvoxamine got sick enough to go. The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). Online Status. Fluvoxamine data for COVID-19 Treatment - COVID-19 Early Treatment Fund Answer (1 of 2): Yes, In a preliminary study of COVID-19 patients with mild-to-moderate disease who were attempting to recover in their homes, researchers at Washington University School of Medicine in St. Louis have found that the drug fluvoxamine seems to prevent some of the most serious compli. Ive talked to doctors who are extremely familiar with the drug and all the trial results and they would prescribe it to their patients. 47).. No more. This looks ominous, but it harmless. But while this effort was praiseworthy, Kirsch's predilection for oversimplifying and exaggerating led him to mislead. Expect similar things to happen when Eiger applies for an EUA for interferon lambda, a drug with a 89% efficacy in phase 3 trials. are all super cheap, effective, and available without a prescription. This is what the Seftel trial at Golden Gate fields used. vocus To protect M10 from my COVID-19 vaccination opinions, I will no longer post about my vaccination concerns here. . One Silicon Valley entrepreneur thought he could beat the odds. Things took a final and dramatic turn once Kirsch started claiming the government was covering up vaccine deaths. That way you can start immediately. It could do nothing. Be warned!. NIH is still unsure whether fluvoxamine should be used to treat COVID (article I did after the TOGETHER trial). See this. I also think it makes a lot of sense to look for pre-existing drugs that can help treat covid symptoms. In other cases, stop cold turkey. Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. Los Altos Hills resident Steve Kirsch funded research into the drug fluvoxamine as a treatment for COVID-19. This document is a collection of evidence that highlights the glaring errors in our pandemic response. Peter Meinke, another former board member, spent nearly three decades in drug discovery at Merck. MisinformationKills. I asked to give a talk about COVID at MIT, but they couldn't find a faculty member to sponsor it. Instead, it erodes confidence in our government to provide timely advice that is in the public interest. I agreed to do it partially because I respect Bob [Siliciano] so much, and partially because I thought the concept was excellent, said former board member Doug Richman, a prominent HIV drug researcher at the University of California San Diego and former member of the funds scientific advisory board. Silicon Valley entrepreneur Steve Kirsch urges the FDA to quickly fluvoxamine - Steve Kirsch Home page Keyword: mit The U of M's study focused on three common drugs: ivermectin, metformin, and fluvoxamine. See the repository above. Today, if we follow the CDC advice, nearly 100,000 people a month will die from COVID. Ms Tech | Pexels (hands); Kirsch (skirsch.com), Ivermectin has been falsely promoted as a covid treatmentbut for those who use the drug legitimately, seeing it become a piece of anti-vaccine misinformation is disconcerting, supports Technology Review's reporting on covid, anti-covid-vaccine, pro-ivermectin pundit, Roomba testers feel misled after intimate images ended up on Facebook, How Rust went from a side project to the worlds most-loved programming language. It's hard to ignore this lecture in explaining why the drug is so effective. According to its founder, serial tech entrepreneur Steve Kirsch, CETF was started in April 2020 in order to fund. I have all of these on hand and I load up on vitamin D3 every day. The case for fluvoxamine for treating COVID-19 - Steve Kirsch Home page I learned this the hard way. But they dont want their names used. YouTube , , , fluvoxamine, , , , , , , , , , You will be wired for 24 hours if you dont heed my advice. Can a common antidepressant help in the fight against COVID-19? . Is that really true? The data is there in plain sight for anyone to see today. On Dr. Drew, he told a story about a friends daughter who had to get an abortion because of damage caused by the shot. . For example, tylenol+caffeine+fluvoxamine can lead to serotonin syndrome. He was recently featured on 60 Minutes which highlighted his . The reason is pure corruption. Doctors wait for government permission (EUA or added to the NIH guidelines) before using a drug. . just like ivermectin). By Steve Kirsch Mar 14, 2021 Fluvoxamine, Proxalutamide, and Ivermectin: 100% success I'm very bullish on two drug combos since it is rare for a single drug to be 100% successful. All can merit a fluvoxamine prescription based on traditional diagnoses. It was completed in August. There is no evidence fluvoxamine is harmful and led to a worse outcome. Today, if we follow the CDC advice, nearly 100,000 people a month will die from COVID. You cannot get any better than that. Its really, really common for a small effect, something that looks exciting, to be a statistical fluke when you look at a larger population. Please, As of November 13, fluvoxamine has been proven to work in every trial that has published results, including, studies. Substitutions. I will . Nobody who took the drug got sick at all, most all wanted to return to work within 3 days after starting treatment. . Have the drug on hand. You will be wired for 24 hours if you dont heed my advice. Its a cycle that feeds mistrust and boosts the profiles of influencers who present themselves in opposition to official authorities. We look for advances that will have a big impact on our lives and break down why they matter.